<b>Purpose</b><br/>The use of adhesive-pad stabilization devices (SDs) instead of suture fixation (SF) may affect dislocation or infection rates. This study aimed to investigate the impact of SDs compared with SF for securing central venous catheters (CVCs). <br/><b>Materials and Methods</b><br/>This multicenter retrospective study was conducted in three tertiary institutions. Two institutions secured CVCs using sutures, whereas one used SDs, between February 2021 and July 2022. Rates of inadvertent dislocation and central line– associated bloodstream infection (CLABSI) were compared using incidence rate ratios (IRRs) from Poisson regression and Kaplan-Meier analysis after propensity-score matching. Factors associated with dislocation and CLABSI were evaluated using Cox proportional hazards analysis. <br/><b>Results</b><br/>A total of 2,110 patients (1,045 female; median age, 61 years [IQR, 50 to 72]) underwent CVC placement (SD, 854; SF, 1,256). After propensity-score matching (455 SD, 666 SF), dislocation occurred more frequently in the SD group (5.85 vs. 2.17 per 1,000 catheter-days; IRR, 2.64; 95% CI, 1.36 to 5.34). CLABSI occurred less frequently in the SD group (IRR, 0.19; 95% CI, 0.04 to 0.54). Kaplan-Meier analysis showed similar results. In multivariable analysis, SD was an independent risk factor for dislocation (adjusted HR [aHR], 2.23; 95% CI, 1.11 to 4.48). SD use showed a protective trend against CLABSI but did not reach statistical significance (aHR, 0.49; 95% CI, 0.13 to 1.82). When dislocation was modeled as a competing event, this protective association reached statistical significance (subdistribution HR, 0.19; 95% CI, 0.05 to 0.66). <br/><b>Conclusion</b><br/>Securement of CVCs with SDs was associated with a higher rate of catheter dislocation. Although SD use was associated with lower CLABSI rates, this finding requires further validation.