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CASE 23 간이식환자에서 경피경간담관배액술 후 합병된 늑골 골수염 Osteomyelitis in the Rib: An Unusual Complication of PTBD in Liver Transplant Patient

정아영 , 김나라 , 이경호 , 김세형 , 김영준 , 정준용 , 한준구 , 최병인
Korean J Interv Radiol 2002;9(1):23.
Published online: December 31, 2002

서울대학교 의과대학 방사선과학교실

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중심단어
Bile ducts, percutaneous drainage Catheters and catheterization, complica-tions Ribs Osteomyelitis
증례
30세/남자
임상소견
윌슨씨 병으로 5개월 전 간이식술 후 수술합병증으로 biliary fistula 가 생겨 경피경간담관배액술 (이후 PTBD) 을 시행하였다. 5개월간 배액관을 가지고 있던 중에 PTBD 상처의 통증을 주소로 내원하였다.
진단명
PTBD tube 에 의한 급성 늑골 골수염
영상소견 및 시술방법
배액관을 이용하여 담관조영술을 시행하였을 때, PTBD tube의 기능은 원활하였다 (Fig. 1A). 환자가 통증을 호소하는 부위에 초음파 검사를 시행하였을 때, 배액관이 삽입된 피부 주위 늑골의 피질 파괴와 주위 연부조직의 종창을 확인 할 수 있었다 (Fig. 1B). 색도플러 검사를 시행하였을 때 이 주변으로 혈류의 증가가 있었다. 단순촬영에서는 특이소견 없었으나, technetium-99m methylene diphosphate 골스캔에서 우측 제 10 늑골에 증가된 섭취를 (hot uptake) 보였다 (Fig. 1C). 초음파 검사 및 골스캔 소견으로 급성 골수염으로 진단하였고, 병변 부위를 피하여 다른 늑골간공간을 통하여 PTBD 을 시행하였고, 기존의 배액관은 제거하였다. 정맥을 통한 항생제 치료 후 PTBD 부위의 통증은 소실되었다.
고찰
간이식술 후 담도계 합병증이 생긴 환자들에서, PTBD 등의 중재적 시술을 통해, 수술적 치료나 재이식을 대부분 피하거나 늦출 수 있으며, 이러한 중재적 시술은 높은 기술적 성공률과 낮은 합병률이 보고되어 있다 (1). 이 증례에서 보인 늑골의 급성 골수염은 PTBD의 매우 드문 합병증으로서, PTBD에 의한 늑골의 합병증에 대해서는 시술 15개월 이후 rib notching 을 보였던 2예 만이 보고된 바 있다 (2, 3). 간이식환자들은 만성적으로 면역억제제를 사용하기 때문에, 배액관을 오랜 기간 동안 가지고 있으면 늑골 골수염을 비롯한 국소적 감염이 더 잘 생길 가능성이 있을 것으로 추측된다.
참고문헌
1. Lorenz JM, Funaki B, Leef JA, Rosenblum JD, Van HT. Percutaneous transhepatic cholangiography and biliary drainage in pediatric liver transplant patients. Am J Roentgenol 2001;176:761-765 2. Severini A, Bellomi M, Cozzi G, Bellegotti L, Lattuada A. Rib erosion: late complication of long-standing biliary drainage catheters. Radiology 1984;150:666 3. Gunther RW, Schild H, Thelen M. Percutaneous transhepatic biliary drainage: experience with 311 procedures. Cardiovasc Invervent Radiol 1988;11:65-71
Fig 1A
A 30-year-old man presented with tenderness and pain at the wound of percutaneous transhepatic biliary drainage (PTBD). He had undergone PTBD five months ago for the management of the biliary fistula at the anastomotic site after living related donor right liver transplantation. A. Cholangiogram using the biliary drainage tube (arrow) shows good position and patency of the drainage tube. Note another pig-tail tube (blank arrow) inserted into the abscess formed by the biliary fistula. B. Ultrasonography of the painful area shows irregular cortical margin of the rib (arrows). Edema of the surrounding soft tissue was also observed compared to contralateral side. C. Technetium-99m methylene diphosphate bone scan revealed a focal increased uptake at the right tenth rib (arrow).
Fig 1B
A 30-year-old man presented with tenderness and pain at the wound of percutaneous transhepatic biliary drainage (PTBD). He had undergone PTBD five months ago for the management of the biliary fistula at the anastomotic site after living related donor right liver transplantation. A. Cholangiogram using the biliary drainage tube (arrow) shows good position and patency of the drainage tube. Note another pig-tail tube (blank arrow) inserted into the abscess formed by the biliary fistula. B. Ultrasonography of the painful area shows irregular cortical margin of the rib (arrows). Edema of the surrounding soft tissue was also observed compared to contralateral side. C. Technetium-99m methylene diphosphate bone scan revealed a focal increased uptake at the right tenth rib (arrow).
Fig 1C
A 30-year-old man presented with tenderness and pain at the wound of percutaneous transhepatic biliary drainage (PTBD). He had undergone PTBD five months ago for the management of the biliary fistula at the anastomotic site after living related donor right liver transplantation. A. Cholangiogram using the biliary drainage tube (arrow) shows good position and patency of the drainage tube. Note another pig-tail tube (blank arrow) inserted into the abscess formed by the biliary fistula. B. Ultrasonography of the painful area shows irregular cortical margin of the rib (arrows). Edema of the surrounding soft tissue was also observed compared to contralateral side. C. Technetium-99m methylene diphosphate bone scan revealed a focal increased uptake at the right tenth rib (arrow).

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CASE 23 간이식환자에서 경피경간담관배액술 후 합병된 늑골 골수염 Osteomyelitis in the Rib: An Unusual Complication of PTBD in Liver Transplant Patient
Korean J Interv Radiol. 2002;9(1):23  Published online December 31, 2002
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CASE 23 간이식환자에서 경피경간담관배액술 후 합병된 늑골 골수염 Osteomyelitis in the Rib: An Unusual Complication of PTBD in Liver Transplant Patient
Korean J Interv Radiol. 2002;9(1):23  Published online December 31, 2002
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